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Original Articles
- C-reactive Protein Concentration Is Associated With a Higher Risk of Mortality in a Rural Korean Population
- Jung Hyun Lee, Hyungseon Yeom, Hyeon Chang Kim, Il Suh, Mi Kyung Kim, Min-Ho Shin, Dong Hoon Shin, Sang-Baek Koh, Song Vogue Ahn, Tae-Yong Lee, So Yeon Ryu, Jae-Sok Song, Hong-Soon Choe, Young-Hoon Lee, Bo Youl Choi
- J Prev Med Public Health. 2016;49(5):275-287. Published online August 23, 2016
- DOI: https://doi.org/10.3961/jpmph.16.025
- 9,087 View
- 201 Download
- 4 Crossref
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Abstract
PDF
Supplementary Material - Objectives
C-reactive protein (CRP), an inflammatory biomarker, has been widely used as a preclinical marker predictive of morbidity and mortality. Although many studies have reported a positive association between CRP and mortality, uncertainty still remains about this association in various populations, especially in rural Korea.
Methods
A total of 23 233 middle-aged participants (8862 men and 14 371 women) who were free from cardiovascular disease, cancer, and acute inflammation (defined by a CRP level ≥10 mg/L) were drawn from 11 rural communities in Korea between 2005 and 2011. Blood CRP concentration was analyzed as a categorical variable (low: 0.0-0.9 mg/L; intermediate: 1.0-3.0 mg/L; high: 3.1-9.9 mg/L) as well as a continuous variable. Each participant’s vital status through December 2013 was confirmed by death statistics from the National Statistical Office. Cox proportional hazard models were used to assess the independent association between CRP and mortality after adjusting for other risk factors.
Results
The total quantity of observed person-years was 57 975 for men and 95 146 for women, and the number of deaths was 649 among men and 367 among women. Compared to the low-CRP group, the adjusted hazard ratio for all-cause mortality of the intermediate group was 1.17 (95% confidence interval [CI], 0.98 to 1.40) for men and 1.27 (95% CI, 1.01 to 1.61) for women, and the corresponding values for the high-CRP group were 1.98 (95% CI, 1.61 to 2.42) for men and 1.41 (95% CI, 1.03 to 1.95) for women. Similar trends were found for CRP evaluated as a continuous variable and for cardiovascular mortality.
Conclusions
Higher CRP concentrations were associated with higher mortality in a rural Korean population, and this association was more prominent in men than in women. -
Summary
Citations
Citations to this article as recorded by
- Binary cutpoint and the combined effect of systolic and diastolic blood pressure on cardiovascular disease mortality: A community-based cohort study
Ju-Yeun Lee, Ji Hoon Hong, Sangjun Lee, Seokyung An, Aesun Shin, Sue K. Park, Tariq Jamal Siddiqi
PLOS ONE.2022; 17(6): e0270510. CrossRef - Association of serum high-sensitivity C reactive protein with risk of mortality in an Asian population: the Health Examinees cohort
Sang-Ah Lee, Sung Ok Kwon, Hyerim Park, Xiao-Ou Shu, Jong-Koo Lee, Daehee Kang
BMJ Open.2022; 12(7): e052630. CrossRef - Associations of C-reactive protein and fibrinogen with mortality from all-causes, cardiovascular disease and cancer among U.S. adults
Junxiu Liu, Yanan Zhang, Carl J. Lavie, Fred K. Tabung, Jiting Xu, Qingwei Hu, Lixia He, Yunxiang Zhang
Preventive Medicine.2020; 139: 106044. CrossRef - Sex differences in the association between self-rated health and high-sensitivity C-reactive protein levels in Koreans: a cross-sectional study using data from the Korea National Health and Nutrition Examination Survey
Se-Won Park, Seong-Sik Park, Eun-Jung Kim, Won-Suk Sung, In-Hyuk Ha, Boyoung Jung
Health and Quality of Life Outcomes.2020;[Epub] CrossRef
- The Association Between Smoking Tobacco After a Diagnosis of Diabetes and the Prevalence of Diabetic Nephropathy in the Korean Male Population
- Hyungseon Yeom, Jung Hyun Lee, Hyeon Chang Kim, Il Suh
- J Prev Med Public Health. 2016;49(2):108-117. Published online March 23, 2016
- DOI: https://doi.org/10.3961/jpmph.15.062
- 9,083 View
- 142 Download
- 16 Crossref
-
Abstract
PDFSupplementary Material
- Objectives
Smoking is known to be associated with nephropathy in patients with diabetes. The distinct effects of smoking before and after diabetes has been diagnosed, however, are not well characterized. We evaluated the association of cigarette smoking before and after a diagnosis of diabetes with the presence of diabetic nephropathy.
Methods
We analyzed data from the 2011-2013 editions of the Korea National Health and Nutrition Examination Survey. A total of 629 male patients diagnosed with diabetes were classified as non-smokers (90 patients), former smokers (225 patients), or continuing smokers (314 patients). A “former smoker” was a patient who smoked only before receiving his diagnosis of diabetes. A “continuing smoker” was a patient who smoked at any time after his diabetes had been diagnosed. Diabetic nephropathy was defined as the presence of albuminuria (spot urine albumin/creatinine ratio ≥30 mg/g) or low estimated glomerular filtration rate (<60 mL/min/1.73 m2). Multiple logistic regression models were used to assess the independent association after adjusting for age, duration of diabetes, hemoglobin A1c, body mass index, systolic blood pressure, medication for hypertension, and medication for dyslipidemia. Female patients were excluded from the study due to the small proportion of females in the survey who smoked.
Results
Compared to non-smokers, continuing smokers had significantly higher odds ratio ([OR], 2.17; 95% confidence interval [CI], 1.23 to 3.83) of suffering from diabetic nephropathy. The corresponding OR (95% CI) for former smokers was 1.26 (0.70 to 2.29).
Conclusions
Smoking after diagnosis of diabetes is significantly associated with the presence of diabetic nephropathy in the Korean male population. -
Summary
Citations
Citations to this article as recorded by- Framework of Guidelines for Management of CKD in Asia
Carol Pollock, Ju-young Moon, Le Pham Ngoc Ha, Pongsathorn Gojaseni, Chen Hua Ching, Lynn Gomez, Tak Mao Chan, Ming-Ju Wu, See Cheng Yeo, Pringgodigdo Nugroho, Anil Kumar Bhalla
Kidney International Reports.2024; 9(4): 752. CrossRef - Relating Onset of Health Conditions to Changes in Tobacco/Nicotine Use — Analyses based on the U.S. PATH Study *
Peter N. Lee, John S. Fry
Contributions to Tobacco & Nicotine Research.2023; 32(1): 1. CrossRef - Nicotine promotes renal interstitial fibrosis via upregulation of XIAP in an alpha7-nAChR-dependent manner
Lili Guo, Yue Zhang, Jian Lu, Xiaoyang Li, Chao Zhang, Wenzhu Song, Yafang Dong, Xiangyang Zhou, Rongshan Li
Molecular and Cellular Endocrinology.2023; 576: 111989. CrossRef - Lifestyle factors associated with a rapid decline in the estimated glomerular filtration rate over two years in older adults with type 2 diabetes–Evidence from a large national database in Japan
Yaya Li, Makoto Fujii, Yuko Ohno, Asuka Ikeda, Kayo Godai, Yuko Nakamura, Yuya Akagi, Daisuke Yabe, Kazuyo Tsushita, Naoki Kashihara, Kei Kamide, Mai Kabayama, Patricia Khashayar
PLOS ONE.2023; 18(12): e0295235. CrossRef - Development of a Risk Model for Predicting Microalbuminuria in the Chinese Population Using Machine Learning Algorithms
Wei Lin, Songchang Shi, Huibin Huang, Nengying Wang, Junping Wen, Gang Chen
Frontiers in Medicine.2022;[Epub] CrossRef - The Global Burden of Type 2 Diabetes Attributable to Tobacco: A Secondary Analysis From the Global Burden of Disease Study 2019
Jianjun Bai, Fang Shi, Yudiyang Ma, Donghui Yang, Chuanhua Yu, Jinhong Cao
Frontiers in Endocrinology.2022;[Epub] CrossRef - ASIAN PACIFIC SOCIETY OF NEPHROLOGY CLINICAL PRACTICE GUIDELINE ON DIABETIC KIDNEY DISEASE
Adrian LIEW, Sunita BAVANANDAN, Narayan PRASAD, Muh Geot WONG, Jer Ming CHANG, Somchai EIAM‐ONG, Chuan‐Ming HAO, Chiao Yuen LIM, Soo Kun LIM, Kook‐Hwan OH, Hirokazu OKADA, Paweena SUSANTITAPHONG, Aida LYDIA, Huong Thi Bich TRAN, Russell VILLANUEVA, See Ch
Nephrology.2020; 25(S2): 12. CrossRef - Impacts of Preoperative Smoking and Smoking Cessation Time on Preoperative Peripheral Blood Inflammatory Indexes and Postoperative Hospitalization Outcome in Male Patients with Lung Cancer and Surgery Treatment
Xu Longming, Dai Shuiping, Zuo Yunxia
Chinese Medical Sciences Journal.2020; 35(2): 170. CrossRef - Interaction of MTHFR C677T polymorphism with smoking in susceptibility to diabetic nephropathy in Chinese men with type 2 diabetes
Liang Ma, Yongwei Jiang, Xiaomu Kong, Qian Liu, Hailing Zhao, Tingting Zhao, Yongtong Cao, Ping Li
Journal of Human Genetics.2019; 64(1): 23. CrossRef - Le tabagisme actif : un facteur de risque majeur des maladies non transmissibles humaines dans une enquête hospitalière
H. Ben Ayed, M. Ben Hmida, M. Ben Jemaa, M. Trigui, J. Jedidi, R. Karray, Y. Mejdoub, M. Kassis, H. Feki, S. Yaich, J. Damak
Revue des Maladies Respiratoires.2019; 36(2): 171. CrossRef - Association of smoking and cardiometabolic parameters with albuminuria in people with type 2 diabetes mellitus: a systematic review and meta-analysis
Debasish Kar, Clare Gillies, Mintu Nath, Kamlesh Khunti, Melanie J. Davies, Samuel Seidu
Acta Diabetologica.2019; 56(8): 839. CrossRef - The global prevalence of tobacco use in type 2 diabetes mellitus patients: A systematic review and meta-analysis
Peter Roderick, Victoria Turner, Anne Readshaw, Omara Dogar, Kamran Siddiqi
Diabetes Research and Clinical Practice.2019; 154: 52. CrossRef - Cigarette smoking and risk of albuminuria in patients with type 2 diabetes: a systematic review and meta-analysis of observational studies
Haili Xu, Jinliu Suo, Jing Lian
International Urology and Nephrology.2018; 50(5): 911. CrossRef - Cigarette smoking and chronic kidney disease in the general population: a systematic review and meta-analysis of prospective cohort studies
Jia Xia, Lin Wang, Zhiheng Ma, Liping Zhong, Ying Wang, Yachan Gao, Liqun He, Xiao Su
Nephrology Dialysis Transplantation.2017; 32(3): 475. CrossRef - Smoking and the risk of diabetic nephropathy in patients with type 1 and type 2 diabetes: a meta-analysis of observational studies
Ning Jiang, Feng Huang, Xiurong Zhang
Oncotarget.2017; 8(54): 93209. CrossRef - Association of single-nucleotide polymorphisms in the RAGE gene and its gene- environment interactions with diabetic nephropathy in Chinese patients with type 2 diabetes
Ying Zhang, Nan Jia, Feng Hu, Naijun Fan, Xiaohua Guo, Han Du, Changlin Mei, Chunfang Gao
Oncotarget.2017; 8(57): 96885. CrossRef
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